The 2021/22 season begins on 23 July with FC Rostov vs Dynamo Moscow. All kickoff times are given in MSK.

Matchday 1

Friday 23 July

20:00 Rostov vs Dynamo

Saturday 24 July

17:30 Khimki vs Zenit
20:00 Lokomotiv vs Arsenal
20:00 Rubin vs Spartak

Sunday 25 July

17:30 Ural vs Krasnodar
19:00 Krylia Sovetov vs Akhmat
20:00 CSKA vs Ufa

Monday 26 July

19:00 Nizhny Novgorod vs Sochi 

Thursday 29 July - Europa Conference League second qualifying round 2nd leg (Sochi)

Matchday 2

Friday 30 July

19:00 Krylia Sovetov vs Spartak
19:00 Arsenal vs Rubin

Saturday 31 July

17:30 Ufa vs Dynamo
20:00 CSKA vs Lokomotiv

Sunday 1 August

17:30 Ural vs Nizhny Novgorod
20:00 Krasnodar vs Khimki
20:00 Rostov vs Zenit

Monday 2 August 

20:00 Akhmat vs Sochi

Tues/Weds 3-4 August - Champions League third qualifying round, first leg (Spartak)

Thursday 5 August - Europa Conference League third qualifying round, first legs (Rubin, and Sochi if they get through the second round)

Matchday 3

Friday 6 August

17:00 Ufa vs Lokomotiv

Saturday 7 August

17:00 Zenit vs Krasnodar
17:30 Arsenal vs Krylia Sovetov
20:00 Spartak vs Nizhny Novgorod

Sunday 8 August

17:30 Khimki vs Rostov
20:00 Rubin vs Akhmat
20:00 Dynamo vs CSKA

Monday 9 August

19:00 Sochi vs Ural

Tuesday 10 August - Champions League third qualifying round, second leg (Spartak)

Thursday 12 August - Europa Conference League third qualifying round, second legs (Rubin,  and Sochi if they get through the second round)

Matchday 4

Saturday 14 August

17:30 Nizhny Novgorod vs Ufa
17:30 Spartak vs Ural
20:00 Akhmat vs Dynamo
20:00 Rostov vs CSKA

Sunday 15 August

17:30 Rubin vs Krylia Sovetov
17:30 Lokomotiv vs Zenit
20:00 Krasnodar vs Arsenal

Monday 16 August

19:00 Sochi vs Khimki

Tues/Weds 17-18 August - Champions League play-off round, first leg (Spartak if they get through the 3rd round)

Thursday 19 August - Europa Conference League play-off round, first legs (Rubin and Sochi if they get through the 3rd round)

Matchday 5

Friday 20 August

17:00 Ural vs Dynamo

Saturday 21 August

17:30 Ufa vs Zenit
17:30 CSKA vs Akhmat
20:00 Arsenal vs Spartak

Sunday 22 August

17:30 Nizhny Novgorod vs Rostov
17:30 Khimki vs Rubin
20:00 Lokomotiv vs Krasnodar

Monday 23 August

18:00 Krylia Sovetov vs Sochi

Tues/Weds 24-25 August - Champions League play-off round, second legs (Spartak if they get through the 3rd round)

Thursday 26 August - Europa Conference League play-off round, second legs (Rubin and Sochi if they get through the 3rd round)

Matchday 6

Saturday 28 August

17:30 Khimki vs Nizhny Novgorod
17:30 Dynamo vs Lokomotiv
20:00 Akhmat vs Arsenal
20:00 Zenit vs CSKA

Sunday 29 August

17:30 Ufa vs Krylia Sovetov
17:30 Ural vs Rostov
20:00 Krasnodar vs Rubin
20:45 Spartak vs Sochi 

30 August - 8 September: International break