On 4 April, after the end of latest Regions Path quarterfinal between Akhmat and Orenburg in the Russian Cup playoffs, the draw procedure was held to determine the pairs of first semifinals stage in the bottom bracket.

Only RPL teams stay following the quarterfinals; these are Dynamo Moscow, FC Rostov, Ural Ekaterinburg, and FC Orenburg.

FC Orenburg vs Dynamo Moscow

Ural Ekaterinburg vs FC Rostov

The fixtures will take place between 16 & 18 April in Orenburg and Ekaterinburg respectively. If regular time end in draw, the penalty shootout will be held. The winners will advance to second semifinals stage of Regions Path, they will host teams eliminated from RPL Path semis.