The draw for the first knockout round of the 2021/22 Russian Cup took place in the Match TV studios.
Dynamo vs Nizhny Novgorod
Spartak vs Kuban
Lokomotiv vs Enisey
Zenit vs KAMAZ
Baltika vs Chayka
Rubin vs Rotor
Alania vs Arsenal
Sochi vs CSKA
Nine Russian Premier Liga teams will take part in the last 16: Zenit, Spartak, Lokomotiv, Rubin, Sochi, Dynamo, CSKA, Nizhny Novgorod and Arsenal. Six more participants represent the second-tier FNL: Kuban, KAMAZ, Alania, Rotor, Baltika, Yenisei. The remaining spot in the draw is taken by the sole third-tier entrant remaining, FNL-2 side Chaika.
Preliminary match dates are 1-3 March 2022.
The current holders of the trophy are Lokomotiv Moscow.